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HRA000863
   HRA000863.xlsx
Title:
Classification and multicellualr heterogeneity of intrahepatic cholangiocarcinoma revealed by single cell transcriptomic analysis
Release date:
2022-02-24
Description:
We performed single cell RNA-seq (scRNA-seq) and Whole Exome Sequencing (WES) on paired normal and tumor tissue of 14 treatment-naive intrahepatic cholangiocarcinoma (iCCA) patients. For scRNA-seq, after doublet removing, quality control for mitochondria percentage and UMI count, we got transcriptomic profiles of 144,878 single-cells, including malignant cells, fibrolasts, endothelial cells and immune cells such as T cell, B cell, NK and myeloid cells. Our study extends the understanding of the diversity of tumor cells in iCCA and provides clearer understanding of iCCA classification.
Data Accessibility:   
Controlled access Request Data
BioProject:
PRJCA005254
Study type:
Disease Study
Disease name:
biliary tract cancer
Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.


DAC NO.:
HDAC000537
DAC name:
Cancer ITH research group
Contact person:
Song Guohe
Email:
docsong2013@163.com
Description:
The major research direction is to study cancer heterogeneity through scRNA-seq.
Individuals & samples
Files
Request Data
Submitter:   Xi Ruibin / ruibinxi@math.pku.edu.cn
Organization:   Peking University
Submission date:   2021-05-24
Requests:   90