NGDC - GSA for Human

HRA000885

HRA000885.xlsx

Title:

A Macrophase Associated LncRNA MALR Facilitates ILF3 Liquid-liquid Phase Separation to Promote Tumor Progression

Release date:

2021-06-01

Description:

Tumor-associated macrophages (TAM) are the most abundant immune cells in tumor microenvironment. Liquid-liquid phase separation (LLPS) occurs in a wide range of biological processes, while its role and the underlying mechanisms in tumor remain obscure. Here, we uncovered a Macrophage Associated LncRNA (MALR) driving LLPS of interleukin enhancer-binding factor 3 (ILF3). MALR is upregulated by TAM and associated with poor prognosis for esophageal squamous cell carcinoma (ESCC). Mechanistically, MALR facilitates malignant phenotypes of ESCC via HIF1A activation via HIF1A MALR promotes ILF3-mediated LLPS by preventing SPOP-mediated ubiquitination. Accordingly, MALR-ILF3-mediated LLPS enhances HIF1A mRNA stability by preventing PARN mediated degradation. Functionally, MALR-ILF3-HIF1A axis promotes tumor malignant progression by enhancing glycolytic activity and facilitating angiogenesis. Clinically, MALR expression significantly correlates with HIF1A pathway activation and ESCC progression.

Data Accessibility:

Controlled access Request Data

BioProject:

PRJCA005288

Study type:

Disease Study

Disease name:

esophageal cancer

Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.

DAC NO.:

HDAC000550

DAC name:

RNA-Seq of esophageal cancer

Contact person:

Kai Yu

Email:

yukai@sysucc.org.cn

Description:

RNA-Seq of esophageal cancer

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