NGDC - GSA for Human

HRA000966

HRA000966.xlsx

Title:

The associations between human sperm DNA fragmentation and DNA methylation

Release date:

2023-06-22

Description:

It is widely accepted that sperm DNA integrity is imperative for successful fertilization, embryo development and pregnancy. High percentage of DNA damaged sperm cells was found in infertile men and negatively affects paternal reproductive capacity. There is a clear association between high level of sperm DNA damage in male and high risk of mutational load or morbidity in the offspring especially in aged or smoking men. As a manifest of sperm DNA damage, sperm DNA fragmentation (SDF) has attracted considerable interest in male infertility research and clinical andrology. SDF is a complicated disorder with diverse associations with genetic, medical, environmental and lifestyle factors that dynamically alter the disorder. DNA methylation is the most studied epigenetic mechanism and emerging as promising frontier in comprehending the epigenetic nature of human sperm.

Data Accessibility:

Controlled access Request Data

BioProject:

PRJCA005481

Study type:

Disease Study

Disease name:

male infertility

Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.

DAC NO.:

HDAC000578

DAC name:

Data Access Committee

Contact person:

Zhu Weijian

Email:

cpm_zwj@wmu.edu.cn

Description:

Data Access Committee

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