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HRA000973
   HRA000973.xlsx
Title:
Single-cell transcriptome sequencing of Kawasaki disease
Release date:
2021-06-25
Description:
Kawasaki disease (KD) is the most common cause of acquired heart disease in children in developed countries. Based on single-cell RNA sequencing (scRNA-seq), we profiled peripheral blood mononuclear cells (PBMCs) from patients with acute KD before and after intravenous immunoglobulin (IVIG) therapy and from healthy controls. We identified the dynamics of cell abundance, gene expression patterns and biological processes underlying the immune dysregulation of each cell compartment. The single-cell landscape of both innate and adaptive immune responses provides new insights into pathogenesis and therapy of KD.
Data Accessibility:   
Controlled access Request Data
BioProject:
PRJCA005497
Study type:
Disease Study
Disease name:
Kawasaki disease
Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.


DAC NO.:
HDAC000582
DAC name:
scRNA-seq Committee of KD
Contact person:
Wang Zhen
Email:
zwang01@sibs.ac.cn
Description:
This committee is a body of named individuals who are responsible for scRNA-seq data of KD release to external requestors based on consent and/or National Research Ethics terms.
Individuals & samples
Files
Request Data
Submitter:   Wang Zhen / zwang01@sibs.ac.cn
Organization:   Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences
Submission date:   2021-06-16
Requests:   -