Single-cell transcriptomic profiling of human colorectal cancer reveals a direct interaction between tumor-specific FAP+ fibroblasts and SPP1+ macrophages
Release date:
Colorectal cancer (CRC) is one of the most common maliganancies. Understanding the tumor microenvironment will benefit the clinical therapy for CRC. Here we used scRNA-seq data from 5 patients, and unraveling a potential interacting cell subsets named MARCO+ macrophages and FAP+ fibroblasts, which may contribute to the formation of a desmoplastic tumor microenvironment and interfere with tumor immunotherapy. We further used spatial transcriptomic analysis to further confirm the potential interaction of these two subsets. Our work highlights the potential therapeutic strategy by disrupting the interaction between these two cell types.
Data Accessibility:   
Controlled access Request Data
Study type:
Disease Study
Disease name:
colorectal cancer
Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.

DAC name:
Youqiong Ye
Contact person:
Ye Youqiong
She is responsible for data release to external requestors based on consent and/or National Research Ethics terms
Individuals & samples
Submitter:   Ye Youqiong /
Organization:   Shanghai Jiao Tong University School of Medicie
Submission date:   2021-06-22
Requests:   50