1. Home
  2. Browse
  3. HRA001112
HRA001112
   HRA001112.xlsx
Title:
Interrogation of the microenvironmental landscape in spinal ependymomas reveals dual functions of tumor-associated macrophages
Release date:
2021-09-28
Description:
Our single-cell RNA-sequencing analyses of three spinal ependymoma subtypes dissected the microenvironmental landscape of spinal ependymomas and revealed tumor-associated macrophage (TAM) subsets with distinct functional phenotypes. CCL2+ TAMs were related to the immune response and exhibited a high capacity for apoptosis, while CD44+ TAMs were associated with tumor angiogenesis. By combining these results with those of scATAC-seq data analysis, we revealed that TEAD1 and EGR3 play roles in regulating the functional diversity of TAMs. We further identified diverse characteristics of both malignant cells and TAMs that might underlie the different malignant degrees of each subtype. Finally, assessment of cell-cell interactions revealed that stromal cells act as extracellular factors that mediate TAM diversity. Overall, our results revealed dual functions of TAMs in tumor progression, providing valuable insights for TAM-targeting immunotherapy.
Data Accessibility:   
Controlled access Request Data
BioProject:
PRJCA005972
Study type:
Disease Study
Disease name:
spinal cord ependymoma
Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.


DAC NO.:
HDAC000115
DAC name:
Xiaoqun Wang Lab
Contact person:
Wang Xiaoqun
Email:
xiaoqunwang@ibp.ac.cn
Description:
Xiaoqun Wang Lab
Individuals & samples
Files
Request Data
Submitter:   Wang Xiaoqun / xiaoqunwang@ibp.ac.cn
Organization:   Institute of Biophysics, Chinese Academy of Sciences
Submission date:   2021-07-28
Requests:   1