1. Home
  2. Browse
  3. HRA001130
HRA001130
   HRA001130.xlsx
Title:
Deciphering cell lineage specification of human lung adenocarcinoma with single-cell RNA sequencing
Release date:
2021-08-13
Description:
In this study, we performed single-cell RNA sequencing of 268,471 cells collected from 25 patients in four histologic stages of LUAD and compared them to normal epithelial cell types. We detected a group of cells closely resembling alveolar type 2 cells (AT2) that emerged during atypical adenomatous hyperplasia and whose transcriptional profile began to diverge from that of AT2 cells as LUAD progressed, taking on feature characteristic of stem-like cells. We identified genes related to energy metabolism and ribosome synthesis that were upregulated in early stages of LUAD and may promote progression. MDK and TIMP1 emerged as potential prognostic biomarkers in LUAD. Taken together, our data shed light on the underlying transcriptional signatures of distinct histologic stages of LUAD progression and may facilitate early diagnosis and prognostic prediction.
Data Accessibility:   
Controlled access Request Data
BioProject:
PRJCA005792
Study type:
Disease Study
Disease name:
lung cancer
Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.


DAC NO.:
HDAC000630
DAC name:
Data Access Committee
Contact person:
Zhoufeng Wang
Email:
wangzhoufeng@wchscu.cn
Description:
Data Access Committee
Individuals & samples
Files
Request Data
Submitter:   Weimin Li / weimi003@scu.edu.cn
Organization:   Frontiers Science Center for Disease-related Molecular Networks, West China Hospital, Sichuan University, Chengdu, Sichuan, China
Submission date:   2021-08-05
Requests:   113