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HRA001175
   HRA001175.xlsx
Title:
Rolling-translated EGFR Variants Sustain EGFR Signaling and Promote Glioblastoma Tumorigenicity
Release date:
2021-08-19
Description:
Aberrant EGFR activation is observed in over 50% of cases of adult glioblastoma (GBM). Nevertheless, EGFR antibodies are ineffective in clinical GBM treatment, suggesting the existence of redundant EGFR activation mechanisms. Whether circular RNA (circRNA) encodes a protein involved in EGFR-driven GBM remains unclear. We reported an unexpected mechanism in which circular EGFR RNA (circ-EGFR) encodes a novel EGFR variant to sustained EGFR activation.These were the linear RNA depeleted(digestion with RNAase R) sequencing data for circRNA detecttion.
Data Accessibility:   
Controlled access Request Data
BioProject:
PRJCA005969
Study type:
Disease Study
Disease name:
glioblastoma classical subtype
Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.


DAC NO.:
HDAC000783
DAC name:
Nu Zhang lab Data Access Committee
Contact person:
Zhang Nu
Email:
zhangnu2@mail.sysu.edu.cn
Description:
Control the Nu Zhang lab's data access in NGDC
Individuals & samples
Files
Request Data
Submitter:   Zhang Nu / zhangnu2@mail.sysu.edu.cn
Organization:   Sun Yat-sen University
Submission date:   2021-08-17
Requests:   -