Methionine Deficiency Facilitates Antitumor Immunity by Altering m6A Methylation of Immune Checkpoint Transcripts
Release date:
2021-10-09
Description:
Methionine metabolism is involved in a myriad of cellular functions, including methylation reactions and redox maintenance. Nevertheless, it remains unclear whether methionine metabolism, RNA methylation and antitumor immunity are molecularly intertwined. Here, we performed RIP-seq to show that methionine-mediated m6A methylation in tumor cells promoted the translation of PD-L1 and VISTA via the m6A-specific binding protein YTHDF1.
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HRA001424.xlsx