Interrogating glioma-M2 macrophage interactions identifies Gal-9/Tim-3 as a viable target against PTEN-null glioblastoma
Release date:
2022-01-06
Description:
Genomic alteration can reshape tumor microenvironment (TME) to drive tumor malignancy. However, it remains unclear how PTEN-deficiency influences microenvironment-mediated cell-cell interactions in glioblastoma (GBM). Here, we show that PTEN-deficiency induces a symbiotic glioma-M2 macrophage interaction to support glioma progression. ScRNA-seq data analysis reveals Gal-9/Tim-3 mediated interactions between glioma cells and macrophages.
Organization: Sun Yat-sen University Cancer Center
Submission date: 2022-01-01
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