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HRA002013
   HRA002013.xlsx
Title:
Integrated profiling of human pancreatic cancer organoids reveals chromatin accessibility features associated with drug sensitivity
Release date:
2022-03-04
Description:
We integrate the chromatin accessibility profiles of 84 pancreatic cancer organoid lines with whole-genome sequencing data, transcriptomic sequencing data and the results of drug sensitivity analysis of 283 epigenetic-related chemicals and 5 chemotherapeutic drugs. We identify distinct transcription factors that distinguish molecular subtypes of pancreatic cancer, predict numerous chromatin accessibility peaks associated with gene regulatory networks, discover regulatory noncoding mutations with potential as cancer drivers, and reveal the chromatin accessibility signatures associated with drug sensitivity. These results not only provide the chromatin accessibility atlas of pancreatic cancer but also suggest a systematic approach to comprehensively understand the gene regulatory network of pancreatic cancer in order to advance diagnosis and potential personalized medicine applications.
Data Accessibility:   
Controlled access Request Data
BioProject:
PRJCA008206
Study type:
Disease Study
Disease name:
pancreatic cancer
Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.


DAC NO.:
HDAC001136
DAC name:
Gao_lab
Contact person:
gao dong
Email:
dong.gao@sibcb.ac.cn
Description:
Key Laboratory of Systems Biology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
Individuals & samples
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Submitter:   gao dong / dong.gao@sibcb.ac.cn
Organization:   Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
Submission date:   2022-02-23
Requests:   9