Integrative analysis of transcriptomics and epigenomics of hypertrophic cardiomyopathy
Release date:
2024-06-26
Description:
Hypertrophic cardiomyopathy (HCM) is an inherited disorder that can leads to atrial fibrillation, heart failure and arrhythmic sudden death. It is characterized by unexplained left-ventricular hypertrophy. In this study, we collected 12 adult human left ventricles from HCM patients and used 8 adult human left ventricles from healthy donors who contributed for other reasons instead of cardiovascular disease and 3 fetal human left ventricles from aborted fetuses. To explore the mechanism of hypertrophic cardiomyopathy, we performed bulk RNA-seq and NOMe-seq for the left ventricle samples.
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HRA002044.xlsx