Research and development of new techniques for preimplantation genetic diagnosis
Release date:
2024-02-14
Description:
Preimplantation genetic testing (PGT) is mainly used in patients with advanced infertility, recurrent miscarriages and repeated implant failure, chromosomal balance translocations, and single gene disease. At present, the pathogenic factors of infertility related to PGT still need to be clarified, and the new PGT technology still needs to be developed and improved. PGT lacks high-quality evidence-based medicine research, and the clinical application system of PGT in China still needs to be improved. In response to the above problems, this project intends to adopt innovative technologies such as single-cell epigenetic parallel multiomics sequencing to analyze the molecular mechanism related to human preimplantation embryo development, and provide theoretical basis for the research and development of new PGT technology. High throughput single molecule sequencing and NICS technology were applied to the new PGT platform.
For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.
This project intends to adopt innovative technologies such as single-cell epigenetic parallel multiomics sequencing to analyze the molecular mechanism related to human preimplantation embryo development, and provide theoretical basis for the research and development of new PGT technology.
Submitter: yuanqing YAO / yaoyuanqing@301hospital.com.cn
Organization: Chinese PLA General Hospital
Submission date: 2022-02-15
Requests: -
Aspera Command Line
You need to install the Aspera Connect plugin before uploading your files. If you dont have Aspera Connect plugin installed in your computer, please Download Aspera Connectand install it first.
[path/to/ascp]: Microsoft Windows: C:\Program Files\Aspera\Aspera Connect\bin\ascp.exe or
c:\users\[username]\AppData\Local\Programs\Aspera\Aspera Connect\bin\ascp.exe
Mac OS X: /Applications/Aspera/Connect.app/Contents/Resources/ascp (for admin's installation) or
/Users/[username]/Applications/Aspera/Connect.app/Contents/Resources/ascp (for non-admin's installation)
Linux: /opt/aspera/bin/ascp or
/home/[username]/aspera/connect/bin/ascp
[path/to/key/file] must be an absolute path, e.g.: /home/keys/aspera.openssh
[path/to/folder/containing/files] needs to specify the local folder that contains all the files to upload.
HRA002053.xlsx