Fumarate Hydratase Deficient Renal Cell Carcinoma (FH-RCC), characterized as carrying pathogenic germline or somatic FH alteration, is a rare subtype of renal cell carcinoma manifested with high invasive and early metastatic potential. However, the distinct multi-omics features and evolutionary relationships between metastatic and primary lesions are still unclear. In this study, whole-exome, RNA and DNA-methylation sequencing were performed for primary-metastatic paired specimens from 19 FH-RCC cases.
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HRA002591.xlsx