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HRA002688
   HRA002688.xlsx
Title:
Single-cell sequencing unveils the transcriptomic and functional alternations in the tuberculosis microenvironment
Release date:
2024-07-12
Description:
In this study, by combining clinical data from 8 individuals, integrating single-cell RNA sequencing (scRNA-seq) and cell surface protein sequencing from 23,990 cells, we not only show four distinct immune phenotypes, but also demonstrate changes in cell population abundance, gene expression, developmental trajectory, transcriptomic regulation, and cell-cell signaling, following infection. MTB immune response was mediated primarily through host T cells, myeloid cells, and natural killer cells, rather than B cells. Specifically, MTB suppressed naive, cytotoxicity and memory functions of T cells, rather than the immunoregulation function. The results allow us to define MTB-host immune cell interactions and propose novel immunotherapeutic treatment strategies to restore T cells from dysfunctional or exhausted states.
Data Accessibility:   
Controlled access Request Data
BioProject:
PRJCA009573
Study type:
Disease Study
Disease name:
Tuberculosis
Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.


DAC NO.:
HDAC001531
DAC name:
Ying binwu
Contact person:
Ying Binwu
Email:
yingbinwu@scu.edu.cn
Description:
Department of Laboratory,West China Hospital of Sichuan University,China.
Individuals & samples
Files
Request Data
Submitter:   Ying Binwu / yingbinwu@scu.edu.cn
Organization:   West China Hospital Sichuan University
Submission date:   2022-07-16
Requests:   1