Single-cell sequencing dissecting dynamic heterogeneity of ascites ecosystem and therapy-induced evolution during gastric cancer peritoneal metastasis
Release date:
2022-12-12
Description:
Gastric cancer peritoneal metastasis (GCPM) has poor prognosis and high mortality with poor therapeutic outcomes. Study of GPCM is complicated since the complexity of the peritoneal ecosystem and the mechanisms of GCPM remain to be deciphered. We characterized single-cell transcriptomes ascites cancer/immune cells from 35 patients with/without GCPM. Our large-scale single-cell data comprehensively delineates the landscape, dynamic changes, and therapy-induced evolution of immune cells and tumor cells in the peritoneal cavity during GCPM, which may provide a new direction for future research on the molecular mechanisms of GCPM and help design effective treatment strategies for GCPM in the future.
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HRA002712.xlsx