NGDC - GSA for Human

HRA002757

HRA002757.xlsx

Title:

Deciphering early human pancreas development at the single-cell level

Release date:

2023-04-19

Description:

Here, we performed scRNA-seq of human embryonic pancreas tissues collected from PCW 4 to 11 and scATAC-seq from PCW 8 to 11. We profiled the major cell types of pancreatic epithelial cells, including dorsal and ventral MP cells, and revealed their molecular heterogeneity and developmental trajectory. We analyzed the transcription factors, regulatory networks and signaling pathways of acinar and ductal lineage cells and revealed a regulatory network of endocrinogenesis and transcription dynamics of EP and endocrine cells. We further compared the developmental trajectories between humans and mice and demonstrated a few distinct features, such as gene expression patterns, in each species. Taken together, our data depict the whole progression of pancreatic organogenesis during the first trimester (PCW 4-11) at the single-cell level.

Data Accessibility:

Controlled access Request Data

BioProject:

PRJCA010743

Study type:

Single cell

Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.

DAC NO.:

HDAC001579

DAC name:

Tao Xu Lab

Contact person:

Xu Tao

Email:

xutao@ibp.ac.cn

Description:

Tao Xu Lab

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