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项目编号 PRJCA010743
项目标题 Deciphering early human pancreas development at single-cell level
涉及领域 Medical
数据类型 Epigenomics
Transcriptome or Gene expression
Single cell sequencing
物种名称 Homo sapiens
描述信息 Here, we performed scRNA-seq of human embryonic pancreas from post-conception week (PCW) 4 to 11 and scATAC-seq from PCW8 to 11. We profiled major cell types of pancreatic epithelial cells including dorsal and ventral MP cells and revealed molecular heterogeneity and developmental trajectory of them. Next, we identified the transcription factor, regulatory network and signal pathway of acinar and ductal linage cells determination. Finally, we revealed regulatory network of endocrinogenesis and transcription dynamics of EP and endocrine cells. Taking together, our data depicted the whole pancreatic organogenesis during the first trimester (PCW 4-11) at single-cell level.
样品范围 Single cell
发布日期 2023-04-19
出版信息
PubMed ID 文章标题 杂志名称 Doi 发表年份
37660175 Deciphering early human pancreas development at the single-cell level Nature Communications 10.1038/s41467-023-40893-8 2023
39406230 Embryonic macrophages support endocrine commitment during human pancreatic differentiation Cell Stem Cell 10.1016/j.stem.2024.09.011 2024
Single-cell multiome analysis supports α-to-β transdifferentiation in human pancreas BioRxiv 10.1101/2025.02.14.638309 2025
39779976 Pancreatic organogenesis mapped through space and time Experimental & Molecular Medicine 10.1038/s12276-024-01384-y 2025
40193385 PPDPF is not a key regulator of human pancreas development PLoS genetics 10.1371/journal.pgen.1011657 2025
Spatially organized cellular communities shape functional tissue architecture in the pancreas BioRxiv 10.1101/2025.04.16.649169 2025
Single-cell multiome analysis supports α-to-β transdifferentiation in human pancreas bioRxiv 10.1101/2025.02.14.638309.full 2025
41223257 Spatially organized cellular communities shape functional tissue architecture in the pancreas Science Advances 10.1126/sciadv.adx5791 2025
41145874 Extracellular matrix-driven metabolic control of pancreatic endocrine lineage allocation EMBO Reports 10.1038/s44319-025-00610-6 2025
40017694 Identification of mouse and human embryonic pancreatic cells with adult Procr + progenitor transcriptomic and epigenomic characteristics Frontiers in Endocrinology 10.3389/fendo.2025.1543960 2025
41689803 Single-cell multi-omic analyses highlight the essential role of NKX2. 2-CLEC16A/endosomal pathway for human pancreatic differentiation and function Cell Reports 10.1016/j.celrep.2026.116990 2026
41484137 Oxidative stress and GPX2 control pancreatic vs. non-pancreatic cell fate in human endoderm Nature Communications 10.1038/s41467-025-68145-x 2026
项目资金来源
机构 项目类型 授权项目ID 授权项目名称
National Natural Science Foundation of China (NSFC) 31730054
National Natural Science Foundation of China (NSFC) 31770900
提交者 Tao Xu (xutao@ibp.ac.cn)
提交单位 Institute of Biophysics, Chinese Academy of Sciences
提交日期 2022-07-23

项目包含数据信息

资源名称 描述
BioSample (19)  show -