NGDC - GSA for Human

HRA002815

HRA002815.xlsx

Title:

ATAC-seq, RNA-seq and ChIP-seq data of high-risk pediatric B-lineage acute lymphoblastic leukemia

Release date:

2023-09-27

Description:

The molecular mechanism of relapse remains unclear for around half of the pediatric B-lineage acute lymphoblastic leukemia (B-ALL). Here, we interpreted the chromatin accessibility features of 61 relapsed B-ALL patients by incorporating whole-genome sequencing (WGS), transcriptome sequencing (RNA-seq) and chromatin immunoprecipitation sequencing (ChIP-seq) data. We showed the increased and rewired chromatin accessibility in B-ALL compared with normal B cells, which were associated with leukemogenesis. By analyzing for differential chromatin accessibility regions between diagnosis and relapse, we identified alterations in chromatin accessibility in response to drug treatment and those associated with relapse free survival. These data provide an integrative portrait of a pediatric B-ALL genome and emphasize the importance of chromatin accessibility alterations in tumorigenesis and drug responses. Totally, the new data set includes 79 ATAC-seq data, 37 RNA-seq data and 24 H3K27ac ChIP-seq data.

Data Accessibility:

Controlled access Request Data

BioProject:

PRJCA011074

Study type:

Cohort Study

Disease name:

acute leukemia

Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.

DAC NO.:

HDAC001629

DAC name:

LiuLab

Contact person:

Liu Yu

Email:

liuyu@scmc.com.cn

Description:

Liu group at Pediatric Translational Medicine Institute

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