METTL3/METTL14 maintain human nucleoli integrity by mediating SUV39H1/H2 degradation
Release date:
2024-07-27
Description:
Here we show that deletion of METTL3 or METTL14 in human embryonic stem cells (hESCs) leads to uncoupling pluripotency gene network from self-renewal. METTL3-/- or METTL14-/- hESCs lost self-renewal but well maintain the expression of typical pluripotency gene network. In contrast, the key cell organelles such as mitochondrial, proteasome, lysosome etc. are impaired in METTL3-/- or METTL14-/- hESCs.
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Individuals & samples
Files
Submitter: Shan Yongli / shan_yongli@gibh.ac.cn
Organization: Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
Submission date: 2022-08-29
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HRA002951.xlsx