Whole-exome sequencing among Chinese patients with hereditary diffuse gastric cancer
Release date:
2024-10-06
Description:
E-cadherin (CDH1) and alpha-E-catenin gene (CTNNA1) were previously identified as hereditary diffuse gastric cancer (HDGC) susceptibility genes, explaining 25-50% of the HDGC cases. The genetic basis underlying disease susceptibility in the remaining 50-75% of HDGC patients is still illusive. Our study provided the genetic landscape for HDGC. We challenged the previous high germline mutation rate of CDH1 in HDGC and reported new potential susceptibility genes. Mutational signature and double-hit events analysis uncovered critical mechanism for HDGC tumorigenesis. The present study provided helpful information for the further investigations of HDGC.
For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.
You need to install the Aspera Connect plugin before uploading your files. If you dont have Aspera Connect plugin installed in your computer, please Download Aspera Connectand install it first.
[path/to/ascp]: Microsoft Windows: C:\Program Files\Aspera\Aspera Connect\bin\ascp.exe or
c:\users\[username]\AppData\Local\Programs\Aspera\Aspera Connect\bin\ascp.exe
Mac OS X: /Applications/Aspera/Connect.app/Contents/Resources/ascp (for admin's installation) or
/Users/[username]/Applications/Aspera/Connect.app/Contents/Resources/ascp (for non-admin's installation)
Linux: /opt/aspera/bin/ascp or
/home/[username]/aspera/connect/bin/ascp
[path/to/key/file] must be an absolute path, e.g.: /home/keys/aspera.openssh
[path/to/folder/containing/files] needs to specify the local folder that contains all the files to upload.
HRA003263.xlsx