Spermine Is a Natural Suppressor of AR Signaling in Castration-Resistant Prostate Cancer
Release date:
2023-06-06
Description:
We demonstrate spermine as an anti-cancer metabolite by inhibiting PRMT1 to transcriptionally inhibit AR-FL and AR-V7 signaling in CRPC, and indicate spermine and PRMT1 inhibition as powerful strategies overcoming limitations of current AR-based therapies in CRPC.
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Organization: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
Submission date: 2023-03-14
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Note: HTTP download speed may be slow. It is highly recommended that you download the dataset using a dedicated FTP tool (such as FileZilla Client) or Asepra Command Line.
HRA004168.xlsx