Hepatitis B virus (HBV) infection has been reported to be associated with pancreatic ductal adenocarcinoma (PDAC). However, the evidence is limited to the epidemiological study. There is still no evidence showing the HBV infection and integration in PDAC cells. Here, we report that HBV DNA is detected in 26.74% (23/86) of the PDAC tissues. Furthermore, by using a high-throughput viral integration detection approach (HIVID), a total of 425 HBV integration sites are identified, among which mixed lineage leukemia gene 4 (MLL4) is found to be repeatedly targeted by HBV in both HCC and PDAC.
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Organization: Renji Hospital, Shanghai Jiao Tong University School of Medicine
Submission date: 2023-07-28
Requests: -
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HRA005175.xlsx