Decoupling acquired and intrinsic chemotherapy resistance from longitudinal sequencing in colorectal liver metastases
Release date:
2024-06-07
Description:
Our team focused on the CRLM population receiving BVZ combined with chemotherapy as the first-line standard treatment, and initially explored the precision treatment of tumor resistance based on the genome and transcriptome sequencing of 49 matched samples obtained from multi-time nodes before and after treatment. Meanwhile, we demonstrate the underlying mechanisms of primary drug resistance mediated by SMAD4R361H missense mutations and secondary drug resistance under hepatocyte/myeloid cell interaction, which provided an analytical template and practical clinical basis for the accurate stratification as well as novel combined strategies of the first-line treatment in CRLM.
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HRA005455.xlsx