Combined anti-PD-1, HDAC inhibitor and anti-VEGF for MSS/pMMR colorectal cancer
Release date:
2024-08-05
Description:
Immune checkpoint inhibitors have demonstrated significant clinical benefits for colorectal cancer (CRC) patients with microsatellite instability-high/deficient mismatch repair (MSI-H/dMMR). However, the majority of CRC patients with microsatellite stable/proficient mismatch repair (MSS/pMMR) exhibit poor response to immunotherapy, and there is currently a lack of effective combination treatments. Building upon our preclinical research findings, we designed a study to investigate the potential efficacy of combining a PD-1 monoclonal antibody, sintilimab, with an HDAC inhibitor, chidamide, with or without bevacizumab, in MSS/pMMR metastatic CRC patients. We conducted an open-label, multicenter trial (NCT04724239) involving patients with MSS/pMMR metastatic CRC who had failed or were intolerant to at least two lines of standard systemic therapies.
For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.
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HRA005462.xlsx