Single cell atlas of Crohn's disease reveals the pivotal role of FAP+ fibroblasts in the microenvironment of intestinal fibrosis
Release date:
2025-01-02
Description:
Intestinal fibrosis, a common complication of Crohn's Disease, is characterized by excessive extracellular matrix (ECM) deposition which induces intestinal strictures. This study aims to identify the main producer of the pathogenic ECM and explore potential therapeutic targets. We obtained the normal and fibrotic intestinal tissues from Crohn's disease patients with intestinal obstruction. Single-cell RNA sequencing (scRNA-seq) was operated on the intestinal specimens.
For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.
Center for Immune-Related Diseases at Shanghai Institute of Immunology, Department of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
You need to install the Aspera Connect plugin before uploading your files. If you dont have Aspera Connect plugin installed in your computer, please Download Aspera Connectand install it first.
[path/to/ascp]: Microsoft Windows: C:\Program Files\Aspera\Aspera Connect\bin\ascp.exe or
c:\users\[username]\AppData\Local\Programs\Aspera\Aspera Connect\bin\ascp.exe
Mac OS X: /Applications/Aspera/Connect.app/Contents/Resources/ascp (for admin's installation) or
/Users/[username]/Applications/Aspera/Connect.app/Contents/Resources/ascp (for non-admin's installation)
Linux: /opt/aspera/bin/ascp or
/home/[username]/aspera/connect/bin/ascp
[path/to/key/file] must be an absolute path, e.g.: /home/keys/aspera.openssh
[path/to/folder/containing/files] needs to specify the local folder that contains all the files to upload.
HRA006083.xlsx