1. Home
  2. Browse
  3. HRA006261
HRA006261
   HRA006261.xlsx
Title:
Single Cell RNA-sequencing Identified CCR7+/RELB+/IRF1+ T cells Responsing for JIA Pathogenesis
Release date:
2023-12-22
Description:
Our study provided evidence of cellular and molecular levels of involvement in JIA pathogenesis and identified the critical roles for T cells in JIA pathogenesis. Furthermore, our results suggested that there were significant differences in T cell composition and gene expression between HLA-B27+ JIA patients and HLA-B27- JIA patients, which may contribute to the phenotypic differences between HLA-B27-positive and HLA-B27-negative JIA subtypes. Our findings indicated that CCR7+/RELB+/IRF1+ triple positive T cells could damage the cartilage of HLA-B27+ JIA by producing cytokines such as IL-17. Taken together, we believe that CCR7+/RELB+/IRF1+ triple positive T cells capable of producing large amounts of cytokines have the potential to serve as prognostic biomarkers in HLA-B27+ JIA patients.
Data Accessibility:   
Controlled access Request Data
BioProject:
PRJCA022036
Study type:
Disease Study
Disease name:
juvenile rheumatoid arthritis
Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.


DAC NO.:
HDAC003482
DAC name:
ScRNA-seq for JIA
Contact person:
Li Yifei
Email:
liyfwcsh@scu.edu.cn
Description:
Our study provided evidence of cellular and molecular levels of involvement in JIA pathogenesis and identified the critical roles for T cells in JIA pathogenesis. Furthermore, our results suggested that there were significant differences in T cell composition and gene expression between HLA-B27+ JIA patients and HLA-B27- JIA patients, which may contribute to the phenotypic differences between HLA-B27-positive and HLA-B27-negative JIA subtypes. Our findings indicated that CCR7+/RELB+/IRF1+ triple positive T cells could damage the cartilage of HLA-B27+ JIA by producing cytokines such as IL-17. Taken together, we believe that CCR7+/RELB+/IRF1+ triple positive T cells capable of producing large amounts of cytokines have the potential to serve as prognostic biomarkers in HLA-B27+ JIA patients.
Individuals & samples
Files
Request Data
Submitter:   Li Yifei / liyfwcsh@scu.edu.cn
Organization:   West China Second University Hospital, Sichuan University
Submission date:   2023-12-15
Requests:   -