Divergent originations of parental DNA hydroxymethylation in human preimplantation embryos
Release date:
2024-06-24
Description:
Epigenetic dysregulation is associated with human infertility and abnormal embryonic development. One important epigenetic modification is DNA 5-hydroxymethylcytosine (5hmC), the conversion of methylcytosine (5mC) to 5hmC by TET enzymes. However, the role of this modification in early human embryos remains largely unknown. Here, we present a single-base-resolution map of 5hmC during human preimplantation development.
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HRA006264.xlsx