Skin organoid modeling of EV71 infection reveals HFMD pathogenesis and aids drug discovery
Release date:
2025-02-19
Description:
The EV71 poses a serious threat to the health and lives of children. The EV71 can be transmitted by direct and indirect skin contact. Therefore, there is an urgent need to create novel skin models using human-derived cells to study the biology and pathogenesis of the virus and facilitate drug screening. In this study, human induced pluripotent stem cell-derived skin organoids (hiPSC-SOs) containing epithelial cells, hair follicles and nerve cells were established to study the effects of EV71 infection on the skin. Single-cell profile of EV71-infected skin organoids were constructed to study the virulence, molecular characteristics and pathogenesis of EV71 infection.
Note: HTTP download speed may be slow. It is highly recommended that you download the dataset using a dedicated FTP tool (such as FileZilla Client) or Asepra Command Line.
Individuals & samples
Files
Submitter: Zhu Yunping / zhuyunping@ncpsb.org.cn
Organization: National center for Protein science (Beijing)
Submission date: 2024-01-11
Aspera Command Line
You need to install the Aspera Connect plugin before uploading your files. If you dont have Aspera Connect plugin installed in your computer, please Download Aspera Connectand install it first.
[path/to/ascp]: Microsoft Windows: C:\Program Files\Aspera\Aspera Connect\bin\ascp.exe or
c:\users\[username]\AppData\Local\Programs\Aspera\Aspera Connect\bin\ascp.exe
Mac OS X: /Applications/Aspera/Connect.app/Contents/Resources/ascp (for admin's installation) or
/Users/[username]/Applications/Aspera/Connect.app/Contents/Resources/ascp (for non-admin's installation)
Linux: /opt/aspera/bin/ascp or
/home/[username]/aspera/connect/bin/ascp
[path/to/key/file] must be an absolute path, e.g.: /home/keys/aspera.openssh
[path/to/folder/containing/files] needs to specify the local folder that contains all the files to upload.
Note: HTTP download speed may be slow. It is highly recommended that you download the dataset using a dedicated FTP tool (such as FileZilla Client) or Asepra Command Line.
HRA006482.xlsx