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HRA006493
   HRA006493.xlsx
Title:
Single-cell RNA-seq of non-small cell lung cancer in response to neoadjuvant combinational immunotherapies
Release date:
2026-01-09
Description:
Multiple combinational immunotherapy regimens are currently being explored in clinical trials. While preclinical studies have provided insights into the mechanisms of these regimens, their efficacy and impact on the tumor microenvironment (TME) in patients are not fully understood. Understanding the dynamics of the TME during different combinational therapies is crucial for optimizing immunotherapy approaches, particularly for patients who do not respond to treatment. Here, we performed single-cell RNA-sequencing (scRNA-seq) analysis on tumor samples from patients diagnosed with non-small cell lung cancer (NSCLC). These samples include paired pre-treatment biopsy and post-neoadjuvant treatment samples with PD-1 inhibitors in combination with either chemotherapy or anti-VEGFA therapy. By integrating the transcriptomic profiles of more than1 million cells, we identified shared and distinct mechanisms within the TME in response to different therapy regimens.
Data Accessibility:   
Controlled access Request Data
BioProject:
PRJCA022724
Study type:
Disease Study
Disease name:
non-small cell lung carcinoma
Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.


DAC NO.:
HDAC001433
DAC name:
Spatial transcriptomic
Contact person:
Zhang Peng
Email:
zhangpeng1121@tongji.edu.cn
Description:
We combined single cell and spatial transcriptomics to identify the spatial landscape of the non-small cell lung cancer (NSCLC) tumor microenvironment (TME) during immunotherapy.
Individuals & samples
Files
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Submitter:   Zhang Peng / zhangpeng1121@tongji.edu.cn
Organization:   Shanghai Pulmonary Hospital Tongji University
Submission date:   2024-01-09
Requests:   2