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HRA006501
   HRA006501.xlsx
Title:
Patient-Derived Organoid Elucidates the Identical Clonal Origin of Bilateral Breast Cancer with Diverse Molecular Subtypes
Release date:
2024-01-16
Description:
We established organoid lines from two surgical tumor specimens of a BBC patient, with one line undergoing detailed pathological and genomic analysis. The derived BBC organoid mirrored the pathological features and breast cancer biomarkers of the original tumor (TNBC from the right breast). Whole Exome Sequencing (WES) revealed that the organoids' copy number variations (CNVs), single nucleotide polymorphisms (SNPs), and insertions/deletions (indels) were more closely aligned with their source tissue (TNBC) than other tumor tissues. Evolutionary analysis suggested that different tumor regions might evolve from a common ancestral layer. In this case, the development of BBC organoids indicated that simultaneous lesions with diverse molecular profiles shared a high degree of consistency in key tumor-driving mutations.
Data Accessibility:   
Controlled access Request Data
BioProject:
PRJCA022774
Study type:
Disease Study
Disease name:
Bilateral breast cancer
Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.


DAC NO.:
HDAC003596
DAC name:
ncology Laboratory
Contact person:
Liang Shanshan
Email:
liangshanshan@dlu.edu.cn
Description:
Group members are responsible for reviewing the applicant's use of the data for the intended purpose.
Individuals & samples
Files
Request Data
Submitter:   Liang Shanshan / liangshanshan@dlu.edu.cn
Organization:   Affiliated Zhongshan Hospital of Dalian University
Submission date:   2024-01-11
Requests:   1