1. Home
  2. Browse
  3. HRA006517
HRA006517
   HRA006517.xlsx
Title:
Chemical programming of human chondrocytes drives cell fitness and promotes cartilage regeneration
Release date:
2024-07-31
Description:
Cell fitness is one of the most vital features that endows the cell graft with the ability to adapt to its new environment, contribute to tissue function and maintain bodily homeostasis. However, there still lacks tractable approaches to achieve this. In this proof-of-concept study, we achieved a safe and cost-effective manipulation of cell fitness in a typical less-fit cell type (human chondrocyte) for tissue regeneration, using a single chemical compound FPH2. Using single-cell transcriptomics, we discovered that FPH2-driven winner status was a result of chemically programmed gene expression associated with energy metabolism, protein synthesis, cell proliferation, cell motility and self-protection. This study proposes an applicable chemical approach to drive cell fitness for tissue regeneration, and provides mechanistic insight into the underpinning molecular machinery.
Data Accessibility:   
Controlled access Request Data
BioProject:
PRJCA015799
Study type:
Chemical-induced cell manipulation
Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.


DAC NO.:
HDAC002423
DAC name:
DAC-610 cartilage
Contact person:
Chen Yishan
Email:
YishanChen@intl.zju.edu.cn
Description:
This DAC includes the PI of the group, the sample collector and the research investigator.
Individuals & samples
Files
Request Data
Submitter:   Ouyang Hongwei / 11418103@zju.edu.cn
Organization:   Zhejiang University
Submission date:   2024-01-18
Requests:   -