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HRA006587
   HRA006587.xlsx
Title:
Distinct intrinsic molecular profiles drive multifaceted cellular instincts in metastatic seeds of primary colorectal cancer
Release date:
2024-01-26
Description:
Metastasis of primary tumors remains a challenge for early diagnosis and prevention. The cellular properties and molecular drivers of metastatically competent clones within primary tumors remain unclear. Here, we generated 10-16 single-cell-derived lines from each of three colorectal cancer (CRC) tumors to identify and characterize metastatic seeds. We found that intrinsic factors conferred clones with distinct metastatic potential and cellular communication capabilities, determining organ-specific metastasis. Poorly differentiated or highly metastatic clones, rather than drug-resistant clones, exhibited poor clinical prognostic impact.
Data Accessibility:   
Controlled access Request Data
BioProject:
PRJCA023187
Study type:
Disease Study
Disease name:
colorectal cancer
Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.


DAC NO.:
HDAC000755
DAC name:
Get data
Contact person:
Wang Xia
Email:
xiawang@mail.tsinghua.edu.cn
Description:
Contact Data Access Committee for Data
Individuals & samples
Files
Request Data
Submitter:   Wang Xia / xiawang@mail.tsinghua.edu.cn
Organization:   Tsinghua University
Submission date:   2024-01-25
Requests:   2