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HRA006931
   HRA006931.xlsx
Title:
Matrix stiffness-tuned exosomes small RNA-seq
Release date:
2024-12-23
Description:
Existing clinical studies have indicated that increased matrix stiffness is positively correlated with an unfavorable prognosis of HCC, and liver stiffness has been taken as a biomarker in clinics to predict HCC progress and its outcome. This study aims to explore whether increased matrix stiffness tuned HCC cell-released exosomal miRNAs trigger HCC metastasis. Exosomes were first isolated and purified from CM of MHCC97H cells grown on low (6 kPa) and high-stiffness (16 kPa) substrates. Small RNAs in exosomes were further subjected to sequencing via the Illumina NovaSeq 6000 platform.
Data Accessibility:   
Controlled access Request Data
BioProject:
PRJCA024399
Study type:
Cell line related study
Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.


DAC NO.:
HDAC003840
DAC name:
Zhongshan Cui
Contact person:
Cui Jiefeng
Email:
cui.jiefeng@zs-hospital.sh.cn
Description:
Members include Pro. Cui and Dr. Zhao.
Individuals & samples
Files
Request Data
Submitter:   Cui Jiefeng / cui.jiefeng@zs-hospital.sh.cn
Organization:   Zhongshan Hospital, Fudan University
Submission date:   2024-03-18
Requests:   -