NGDC - GSA for Human

HRA007076

HRA007076.xlsx

Title:

gastric cancer cell free microbiome RNA sequencing

Release date:

2024-04-11

Description:

In this study, we conducted a comprehensive examination of microbiome profiles using plasma cfRNA in a cohort comprising 224 participants, including 112 healthy individuals and 112 patients at four distinct stages of GC. Significant differences in microbial composition were discovered between the two groups, establishing the potential of using plasma cfRNA for GC microbiome profiling. Through the application of machine learning techniques, we developed models that effectively differentiated between healthy individuals and GC patients, thereby showcasing the diagnostic utility of the microbiome signature. Our analysis further unveiled specific microorganisms intricately associated with different stages of GC, therefore reinforcing findings from prior gut metagenomic studies. Importantly, our study highlights the gastrointestinal microbiome as a valuable source for plasma microbiome cfRNA analysis.

Data Accessibility:

Controlled access Request Data

BioProject:

PRJCA024540

Study type:

Disease Study

Disease name:

stomach cancer

Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.

DAC NO.:

HDAC003867

DAC name:

gastric cancer

Contact person:

He Yaqin

Email:

heyq3342@hotmail.com

Description:

gastric cancer cell free microbiome RNA sequencing

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