HRA007441
Title:
Tumor vasculature at single-cell resolution
Release date:
2024-05-24
Description:
Tumor growth cannot flourish without the oxygen and nutrients supplied by the blood, making angiogenesis induction one of the most critical cancer hallmarks. In this study, we generated a pan-tumor vasculature atlas by integrating in-house and public single-cell datasets. At the single-cell resolution, we dissected ~200,000 vascular cells, including vascular endothelial cells (ECs), lymphatic ECs (LECs), and mural cells (MCs). Our findings contributed to understanding the tumor angiogenesis processes, LEC lineages, MC phenotypes, and intercellular interactions associated with the tumor vascular microenvironment (TVM). Our comprehensive TVM compilations complemented a missing piece of jigsaw puzzle for the single-cell pan-tumor atlas and provided a reference perspective on tumor vascular normalization and anti-angiogenic therapy.
Data Accessibility:   
Controlled access Request Data
BioProject:
Study type:
Disease Study
Disease name:
Cancer
Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.


DAC NO.:
DAC name:
Yin Lab.
Contact person:
Yin Mingzhu
Email:
yinmingzhu2008@126.com
Description:
Yin Lab.
Individuals & samples
Submitter:   Yin Mingzhu / yinmingzhu2008@126.com
Organization:   Chongqing University Three Gorges Hospital
Submission date:   2024-05-13
Requests:   9