The human cornea undergoes age-related changes that impact ocular tissue function and susceptibility to disease. We present a high-resolution spatiotemporal transcriptomic and cell type atlas of human corneas obtained from male donors across different age groups. By integrating spatial transcriptomics (scStereo-seq) with single-cell RNA sequencing (scRNA-seq), we reveal age-related variability in gene expression, cellular composition, and spatial organization within major corneal cell types.
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HRA007528.xlsx