The human cornea, a crucial component of the visual system, undergoes age-related changes that affect the function of ocular tissues and increase susceptibility to diseases. Despite its clinical importance, the precise cellular and molecular mechanisms underlying corneal aging remain partially understood. In this study, we present a detailed spatiotemporal transcriptomic and cell type atlas of human corneas obtained from male donors across various age groups. By combining spatial transcriptomics (scStereo-seq) with single-cell RNA sequencing (scRNA-seq), we uncover age-related variations in gene expression, cellular composition, and spatial organization within major corneal cell types.
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HRA007620.xlsx