Single-cell transcriptome in patients with locally advanced cervical cancer treated with concurrent chemoradiotherapy sequencial with PD-1 inhibitor
Release date:
2025-10-26
Description:
Radiotherapy is the first-line treatment for locally advanced cervical squamous cell cancer (CSCC), however, approximately 50% of patients progressed after radical radiotherapy and the molecular mechanisms are unclear. Thus, understanding of the role of concurrent chemoradiotherapy sequential PD-1 inhibitor and the molecular responses of different cell types in tumor exposed to radiotherapy or ICI is pivotal for improving the efficiency or causing the side effects in CSCC treatment. Here, we performed multi-omics, such as single-cell RNA-seq, bulk RNAseq and TCR/BCR sequencing et al to construct high-resolution molecular landscape of various cell types in CSCC before and during radiotherapy and ICI.
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Radiotherapy is the first-line treatment for locally advanced cervical squamous cell cancer (CSCC), however, approximately 50% of patients progressed after radical radiotherapy and the molecular mechanisms are unclear. Thus, understanding of molecular responses of different cell types in tumor exposed to radiotherapy is pivotal for improving the efficiency of radiotherapy in CSCC, but single-cell level studies remain lacking. Here, we performed single-nucleus RNA-seq to construct high-resolution molecular landscape of various cell types in CSCC before and during radiotherapy.
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HRA008063.xlsx