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HRA008128
   HRA008128.xlsx
Title:
CCL19-producing fibroblasts promote tertiary lymphoid structures formation augmenting anti-tumor IgG response in colorectal cancer liver metastasis
Release date:
2024-08-12
Description:
We provide a comprehensive comparative analysis of the immune ecosystems of CRLM with or without TLSs by spatial enhanced resolution omics-sequencing (Stereo-seq) (from 10 patients) and single cell RNA-sequencing (scRNA-seq) (from 14 patients). We disclose an important link between IgG+ PCs and TLSs, underlining the crucial role of IgG responses in anti-tumor immunity. We also find that fibroblast-derived CCL19 regulate B cell recruitment and TLSs formation, which can be a promising target to promote TLSs neogenesis and suppress CRLM growth.
Data Accessibility:   
Controlled access Request Data
BioProject:
PRJCA026987
Study type:
Disease Study
Disease name:
liver cancer
Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.


DAC NO.:
HDAC004220
DAC name:
CRC_LM_TLS
Contact person:
Kuang Ming
Email:
kuangm@mail.sysu.edu.cn
Description:
We provide a comprehensive comparative analysis of the immune ecosystems of CRLM with or without TLSs by spatial enhanced resolution omics-sequencing (Stereo-seq) (from 10 patients) and single cell RNA-sequencing (scRNA-seq) (from 14 patients). We disclose an important link between IgG+ PCs and TLSs, underlining the crucial role of IgG responses in anti-tumor immunity. We also find that fibroblast-derived CCL19 regulate B cell recruitment and TLSs formation, which can be a promising target to promote TLSs neogenesis and suppress CRLM growth.
Individuals & samples
Files
Request Data
Submitter:   Kuang Ming / kuangm@mail.sysu.edu.cn
Organization:   The First Affiliated Hospital, Sun Yat-sen University
Submission date:   2024-06-12
Requests:   10