NGDC - GSA for Human

HRA008234

HRA008234.xlsx

Title:

Single-Cell RNA Sequencing in Esophageal Small Cell Carcinoma Following Chemotherapy Treatment

Release date:

2024-12-21

Description:

Small cell carcinoma of the esophagus (SCCE) is a rare, aggressive malignancy presenting significant clinical challenges. Chemotherapy manages early-stage symptoms but has limited long-term effectiveness, with mechanisms poorly understood. We used single-cell RNA sequencing (scRNA-seq) to analyze SCCE samples from a patient before and after chemotherapy. Our findings showed notable cellular plasticity and changes in the tumor microenvironment. Tumor cell diversity increased, while T cells, B cells, and myeloid-like cells decreased. Pre-treatment samples featured carcinoma cells in a middle transitional state, while post-treatment samples showed cells in terminal, initial-to-terminal (IniTerm), and universally altered states. Further analysis revealed dynamic tumor-immune cell interactions and changes in key signaling pathways like TIGIT-PVR and MDK-SDC4. This study sheds light on cell plasticity dynamics in SCCE post-chemotherapy, offering new insights and potential therapeutic targets for improved treatment.

Data Accessibility:

Controlled access Request Data

BioProject:

PRJCA028778

Study type:

Disease Study

Disease name:

esophageal carcinoma

Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.

DAC NO.:

HDAC003958

DAC name:

Data Management Committee

Contact person:

Wei Zhao

Email:

zhaowei23@mail.sysu.edu.cn

Description:

The Data Management Committee is responsible for managing data and processing data access requests.

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