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HRA008537
   HRA008537.xlsx
Title:
Unveiling potential microbial markers for metastatic colorectal cancer: Identification of gut and intratumoral microbiota and modelling for distant metastasis prediction
Release date:
2024-09-13
Description:
In this study, we conducted 16S rRNA gene sequencing of fecal samples obtained from CRC patients with and without distant metastasis, aiming to discern the gut microbiota associated with distant metastasis. Moreover, employing the BIC database, we sought to identify intratumoral microbiota linked to distant metastasis. Concurrently, our study delved into the correlation among gut and intratumoral microbiota associated with CRC distant metastasis, immune-related genes, immune infiltrating cells, and pertinent biological pathways. Last but not the least, leveraging the gut microbiota associated with distant metastasis of CRC, we constructed RF model demonstrating predictive significance. These findings held promise in furnishing novel insights pertinent to the diagnosis and therapeutic management of metastatic CRC.
Data Accessibility:   
Controlled access Request Data
BioProject:
PRJCA029964
Study type:
Human metagenome
Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.


DAC NO.:
HDAC003823
DAC name:
Division of Colorectal Surgery
Contact person:
Tang Weizhong
Email:
tangweizhong@gxmu.edu.cn
Description:
We collected fecal sample and clinical data from CRC patients and peformed microbiota-associated and bioinformatics analysis.
Individuals & samples
Files
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Submitter:   Tang Weizhong / tangweizhong@gxmu.edu.cn
Organization:   Guangxi Medical University Cancer Hospital
Submission date:   2024-09-07
Requests:   -