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HRA009475
   HRA009475.xlsx
Title:
ALCAM is an Entry Factor for Severe Community Acquired Pneumonia-associated Human Adenovirus Species B
Release date:
2024-12-04
Description:
Human adenovirus (HAdV) is one of the most widely spread respiratory pathogens that can cause infections in multiple tissues and organs. Previous studies have established an association between HAdV species B (HAdV-B) infection and severe community-acquired pneumonia (SCAP). However, the connection between SCAP-associated HAdV-B infection and host factor expression profile in patients has not been systematically investigated. Here, we performed CRISPR genetic screen on HAdV-B using two generations of cell surface protein-focused CRISPR libraries and identified a series of host factors including the known receptor DSG-2 and an unknown factor activated leukocyte cell adhesion molecule (ALCAM). Further investigation has shown that ALCAM affects HAdV-B infection by participating in viral internalization. Most importantly, re-visit of the clinical samples has uncovered that ALCAM has significantly higher expression in SCAP patients with HAdV-B infection than in those with other infections.
Data Accessibility:   
Controlled access Request Data
BioProject:
PRJCA032741
Study type:
Disease Study
Disease name:
pneumonia
Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.


DAC NO.:
HDAC005071
DAC name:
SCAP DAC
Contact person:
Qu Jieming
Email:
jmqu0906@163.com
Description:
Data Access Committee for project SCAP
Individuals & samples
Files
Request Data
Submitter:   Qu Jieming / jmqu0906@163.com
Organization:   Ruijin Hospital Institute of Respiratory Diseases, School of Medicine, Shanghai Jiao-Tong University
Submission date:   2024-11-28
Requests:   -