Deciphering signaling mechanisms and developmental dynamics in extraembryonic mesoderm specification from hESCs
Release date:
2025-04-07
Description:
We demonstrate that the modulation of BMP, WNT, and Nodal signaling pathways can rapidly and efficiently induce the differentiation of both naive and primed hESCs into ExM-like cells (ExMs), predominantly through intermediates exhibiting a primitive streak (PS)-like phenotype. We reveal the regulatory roles of WNT and Nodal signaling in ExM specification from hESCs. Furthermore, we find that the initial pluripotent state influences hESC-based ExM specification, including signal response, cellular composition, developmental progression, and transcriptional characteristics of the resulting ExMs.
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Individuals & samples
Files
Submitter: Yin Yu / yiny@lpbr.cn
Organization: Institute of Primate Translational Medicine, Kunming University of Science and Technology
Submission date: 2025-03-07
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HRA010716.xlsx