Spatial multi-omics uncovering tumor structures and cell type specific metabolites in primary and microvascular invasion HCC
Release date:
2025-05-09
Description:
In this study, we collected the tumor boundary tissues of MVI+ and MVI- patients, along with distant paratumor tissues, and performed spatial transcriptome and metabolism sequencing. By comparing gene expression and metabolite signal intensities between MVI+ and MVI- tissues, we observed significant alterations in lipid metabolism activities within tumor and peritumoral regions during HCC progression from MVI- to MVI+.
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HRA011344.xlsx