S100a4+ alveolar macrophages accelerate the progression of precancerous atypical adenomatous hyperplasia by promoting the angiogenic function regulated by fatty acid metabolism.
Release date:
2025-05-28
Description:
Single-cell interaction and metabolic analyses highlighted a cellular state, S100a4+ alveolar macrophages, which exhibited distinct fatty acid metabolic activity, such as palmitic acid metabolism, at the atypical adenomatous hyperplasia stage, accompanied by an angiogenic-promoting function in a pre-neoplastic setting of mice. These findings were reproducible in human single-cell transcriptomes and had been confirmed by histopathological staining and in vitro cell coculture assays.
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Individuals & samples
Files
Submitter: li Zhang / zhangli7375@scu.edu.cn
Organization: West China Medical Center,Sichuan Medical University
Submission date: 2025-05-19
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HRA011594.xlsx