Allogeneic T cells with anti-CD19 STAR integrated into TRAC locus induce immune resetting and sustained remission in refractory systemic lupus erythematosus with severe lupus nephritis
Release date:
2025-06-07
Description:
YTS109 is a hypoimmune allogeneic STAR-T cell product engineered via CRISPR/Cas9 to overcome the limitations of autologous CAR-T therapies, including cost, manufacturing complexity, and insertional mutagenesis risk. In patients with refractory systemic lupus erythematosus and lupus nephritis, YTS109 induced immune resetting and significant clinical remission, offering a promising new therapeutic approach.
For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.
YTS109 is a hypoimmune allogeneic STAR-T cell product engineered via CRISPR/Cas9 to overcome the limitations of autologous CAR-T therapies, including cost, manufacturing complexity, and insertional mutagenesis risk. In patients with refractory systemic lupus erythematosus and lupus nephritis, YTS109 induced immune resetting and significant clinical remission, offering a promising new therapeutic approach.
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HRA011753.xlsx