1. Home
  2. Browse
  3. HRA012395
HRA012395
   HRA012395.xlsx
Title:
ZNF683+ NK cells govern chemotherapy sensitivity in advanced HPSCC via reshaping immune microenvironment
Release date:
2026-01-06
Description:
Hypopharyngeal squamous cell carcinoma (HPSCC), an aggressive head and neck cancer with dismal prognosis, faces persistent chemoresistance to standard TPF (docetaxel, cisplatin, 5-fluorouracil) regimen. However, the immunological mechanisms underlying chemoresistance remain undefined. Here, we performed longitudinal single-cell RNA sequencing (scRNA-seq) profiling of paired pre-/post-TPF HPSCC specimens, mapping immune cell dynamics underlying chemoresistance.
Data Accessibility:   
Controlled access Request Data
BioProject:
PRJCA043247
Study type:
Disease Study
Disease name:
hypopharynx cancer
Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.


DAC NO.:
HDAC006403
DAC name:
advanced HPSCC
Contact person:
Li Guo
Email:
liguoent@csu.edu.cn
Description:
Hypopharyngeal squamous cell carcinoma (HPSCC), an aggressive head and neck cancer with dismal prognosis, faces persistent chemoresistance to standard TPF (docetaxel, cisplatin, 5-fluorouracil) regimen. However, the immunological mechanisms underlying chemoresistance remain undefined. Here, we performed longitudinal single-cell RNA sequencing (scRNA-seq) profiling of paired pre-/post-TPF HPSCC specimens, mapping immune cell dynamics underlying chemoresistance.
Individuals & samples
Files
Request Data
Submitter:   Li Guo / liguoent@csu.edu.cn
Organization:   Department of Otolaryngology Head and Neck Surgery
Submission date:   2025-07-15
Requests:   1