Bulk RNA-seq profiling of CAFs differentiated from fibroblasts isolated from human lung cancer and adjacent normal lung tissue
Release date:
2025-10-30
Description:
To comprehensively characterize the transcriptomic profiles and investigate the phenotypes and functions of LRRC15+ CAFs, we used transforming growth factor-b (TGF-b) to induce human lung fibroblasts into LRRC15-expressing myCAFs. Primary fibroblasts were isolated from human lung carcinoma tissues and matched adjacent normal lung tissues. We performed bulk RNA sequencing on these in vitro differentiated CAF populations.
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HRA014267.xlsx