Efficacy and immunomodulatory effect of Claudin18.2-specific IL-7/XCL1 armored CAR-T cells in digestive tract cancer: Preclinical and clinical analysis
Release date:
2026-01-14
Description:
CAR-T cell therapy has limited efficacy in solid tumors, such as digestive tract cancer (DTC), largely because of the tumor microenvironment (TME) and the limitations of CAR-T cell function. Here, we constructed fourth-generation CLDN18.2-targeted CAR-T cells that concurrently secrete IL-7 and XCL1(ExCAR-T cells, also referred to as RD07 in clinical trial).
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Organization: The First Affiliated Hospital of Zhengzhou University
Submission date: 2026-01-09
Requests: -
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